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        Nc2Eye

           A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of age-related macular degeneration (AMD)
ncRNA name FABP5 siRNA
ncRNA Category siRNA
Disease name age-related macular degeneration (AMD)
Species Homo sapiens
Tissues/Cell_line human RPE cell line ARPE-19
Methods siRNA transfection,qRT-PCR, Western blot, Fatty acid uptake assay, Nile Red staining, Electrospray tandem mass spectrometry, immunoprecipitation
Expression pattern associated
Functional description FABP5 downregulation in the RPE/choroid complex in vivo might contribute to aging and early age-related macular degeneration.
PubMed ID 19434059
Year 2010
Title Knockdown of FABP5 mRNA decreases cellular cholesterol levels and results in decreased apoB100 secretion and triglyceride accumulation in ARPE-19 cells.
Drug-related ncRNA NO

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